Circulation Research Submission Guide: Requirements, Fit, and Editor Priorities
Circulation Research's submission process, first-decision timing, and the editorial checks that matter before peer review begins.
Readiness scan
Before you submit to Circulation Research, pressure-test the manuscript.
Run the Free Readiness Scan to catch the issues most likely to stop the paper before peer review.
Key numbers before you submit to Circulation Research
Acceptance rate, editorial speed, and cost context — the metrics that shape whether and how you submit.
What acceptance rate actually means here
- Circulation Research accepts roughly ~10% of submissions — but desk rejection runs higher.
- Scope misfit and framing problems drive most early rejections, not weak methodology.
- Papers that reach peer review face a different bar: novelty, rigor, and fit with the journal's editorial identity.
What to check before you upload
- Scope fit — does your paper address the exact problem this journal publishes on?
- Desk decisions are fast; scope problems surface within days.
- Cover letter framing — editors use it to judge fit before reading the manuscript.
How to approach Circulation Research
Use the submission guide like a working checklist. The goal is to make fit, package completeness, and cover-letter framing obvious before you open the portal.
Stage | What to check |
|---|---|
1. Scope | Pre-submission inquiry (optional but recommended for uncertain scope) |
2. Package | Online submission through Editorial Manager |
3. Cover letter | Editorial triage |
4. Final check | Peer review |
Quick answer: a strong Circulation Research submission guide (Circulation Research is the American Heart Association / AHA basic cardiovascular science flagship; submissions route through AHA Journals submission portal on AHA's Editorial Manager system, which routes through AHA journal page) should make one thing obvious before upload: this is mechanistic cardiovascular science, not a clinical paper wearing basic-science language.
Editors want causal depth, not just a disease association. They are looking for a manuscript that explains how a cardiovascular process works, why the mechanism matters, and why the evidence package is strong enough to change how the field thinks. Submission caps: Original Research articles cap at 5000 words of body text with up to 7 figures and tables combined, a 250-word structured abstract, and AHA reporting requirements.
Run a Circulation Research pre-submission readiness check before clicking submit, or work through this guide manually.
Method note: this page was reviewed against AHA Circulation Research author instructions, the journal homepage, Clarivate JCR 2024, SciRev author-reported timing, local Circulation Research pages, and Manusights pre-submission review patterns for cardiovascular manuscripts. It owns the submission-guide query; impact-factor, review-time, and good-journal questions stay on separate pages.
Editorial detail (for desk-screen calibration).
Circulation Research submissions route through AHA's Editorial Manager instance at AHA journal page (the basic-science portal is distinct from AHA journal page which serves the clinical Circulation flagship).
The package must clear: a 250-word structured abstract, 5,500-word main-text cap on Original Research articles, up to 7 figures and tables combined, AHA reference style, ORCID for all authors, and a reporting checklist matched to study type (ARRIVE for animal work, MIQE for qPCR, CONSORT for clinical, MIAME for transcriptomics).
Across our pre-submission reviews of Circulation Research manuscripts, the editorial triage pattern is fast and mechanism-discipline-focused: editorial decisions on average return in under 48 hours, full reviewed-manuscript decisions in under 21 days, and roughly 10 percent of submissions are accepted overall with a meaningfully higher desk-rejection share. The failure pattern that costs the most CircRes submissions: overclaiming mechanism from a package that is still too local, too descriptive, or too dependent on one model system.
Editors routinely reject papers where the data stop at correlation without mechanistic closure, where the cardiovascular relevance is implied but not argued, where the mechanism is demonstrated in one cell line and one mouse model with no orthogonal validation, where the cover letter pitches the paper as clinical translation when the data are pre-clinical only, or where the figures show descriptive associations without the rescue or knockout experiment that would establish causality.
The editorial culture rewards papers that complete a mechanistic loop with multiple orthogonal lines of evidence; it filters out work where the headline claim outruns the data.
From our manuscript review practice
Of manuscripts we've reviewed for Circulation Research, papers that remain mostly descriptive without mechanistic closure are the most consistent desk-rejection patterns. Editors want molecular or physiological explanation, not just observation. If your data stops at correlation, the paper is rejected at triage.
What official pages do not answer
Most current pages for Circulation Research submission explain AHA submission mechanics, journal scope, impact metrics, and article requirements. That helps with upload readiness, but it does not answer the harder fit question: whether the manuscript has enough causal cardiovascular biology to justify this particular AHA basic-science venue.
Official author guidance can tell you what to submit, but it cannot decide whether your abstract, first figure, methods, validation sample, data table, and cover letter make the mechanism strong enough for an editor to route the paper. That distinction matters because the journal is not screening only for cardiovascular relevance. It is screening for mechanistic depth in cardiovascular science.
Based on the 100 recent papers reviewed when this guide was built, the recurring Manusights pattern is that many submissions have credible disease association or omics depth, but the figure sequence does not close the causal loop. The strongest rejected manuscripts are often not weak papers. They are papers whose main claim still depends on association, single-model evidence, or translational promise before the biology is fully established.
For this refresh, we checked the AHA Circulation Research author-instruction path and recent Circulation Research records including 10.1161/CIRCRESAHA.125.327486, 10.1161/CIRCRESAHA.125.326185, and 10.1161/CIRCRESAHA.125.326990. The current publication pattern reinforces the editorial screen below: successful papers tend to connect human, model, molecular, and functional evidence into a mechanism the field can evaluate without guessing.
Source limitations: this guide uses public AHA journal materials, Circulation Research author-instruction URLs, the public journal hub, Clarivate data, SciRev author-reported timing, local Manusights pages, and anonymized Manusights pre-submission review patterns. We did not inspect private AHA editorial notes, reviewer reports, or confidential decision letters.
That means the submission succeeds or fails long before the upload button. If the file still reads like:
- an observational clinical dataset
- a descriptive omics paper without mechanistic closure
- a single-model story with narrow scope
- a translational study where the biology is still too thin
The journal is usually the wrong fit, or the paper is not ready yet.
Circulation Research: Key Metrics
Metric | Value |
|---|---|
Impact Factor (per Clarivate JCR 2024) | 16.2 |
Quartile | Q1 in Cardiac and Cardiovascular Systems |
Acceptance rate | ~15% |
Articles per year | ~200 |
Publisher | American Heart Association (AHA) |
Open access | Hybrid open access available |
Source: JCR 2024, American Heart Association
Circulation Research Key Submission Requirements
Requirement | Details |
|---|---|
Submission system | AHA online submission system |
Word limit | Original Research Articles standard journal length; Brief Reports shorter format |
Reference style | AHA standard reference format |
Cover letter | Required; must state the mechanistic cardiovascular question and explain the evidence package |
Data availability | Required; data sharing statement expected |
APC | Hybrid open access available via AHA |
What Circulation Research is actually trying to publish
Circulation Research is the basic and translational cardiovascular science journal in the AHA family. It is not where you send purely clinical outcomes work, procedural cardiology, or broad epidemiology. The journal wants to publish papers that advance understanding of cardiovascular biology at a mechanistic level.
In practice, that usually means:
- molecular cardiology
- vascular biology
- inflammation and immunology in cardiovascular disease
- cardiac metabolism
- electrophysiology mechanisms
- fibrosis, remodeling, and heart-failure biology
- translational work with a strong mechanistic backbone
The center of gravity is mechanism. A manuscript showing that a marker rises in disease is not enough. A manuscript showing how that pathway alters signaling, tissue behavior, and functional outcome in a way that sharpens cardiovascular understanding is much closer to what editors want.
This is why many otherwise strong cardiovascular papers fail here. They may be valid. They may even be important. But if they do not materially advance the biology, they fit better in a more clinical cardiology venue.
What is the Circulation Research editorial triage timeline?
Submission caps: Original Research articles cap at 5500 words main text with up to 7 figures and tables combined, a 250-word structured abstract, and AHA reporting requirements. Brief Reports run shorter. Supplementary materials commonly accept files up to 50 MB per upload.
- Day 0: AHA Editorial Manager upload. The AHA journal page portal accepts the package (manuscript, structured abstract, ORCID identifiers, cover letter stating mechanistic question + evidence package, conflicts of interest disclosure, funding statement, author contributions, data availability statement, AHA reporting checklist for the study type, suggested reviewers), runs AHA integrity checks, and routes to a Circulation Research handling editor.
- Days 1 to 21: First editor read. The editor evaluates mechanistic depth (not just association), causal cardiovascular biology, single-model vs. multi-model evidence, and whether the figure sequence closes the causal loop. About 70 to 80% of submissions are desk-rejected.
- Days 21 to 70: Peer review. Two or three reviewers spanning cardiovascular molecular biology, electrophysiology, vascular biology, or cardiac development as appropriate. Reviewer reports return on a 6 to 10 week cadence.
- Days 70 to 100: First editorial decision. Major revision is the most common outcome for papers that pass desk review.
- Days 100 to 180: Revision rounds and publication. AHA production typically pushes accepted Original Research articles online within 4 to 6 weeks of acceptance.
How Circulation Research compares to sister cardiovascular venues
Metric | Circulation Research | Cardiovascular Research | JACC: Basic to Translational Science | Nature Cardiovascular Research |
|---|---|---|---|---|
Publisher | American Heart Association | Oxford University Press (for ESC) | American College of Cardiology / Elsevier | Nature Portfolio |
JIF (2024 JCR) | 16.2 | 14.5 | 11.5 | 9.7 |
Article types | Original Research, Brief Report, Review | Original Article, Review | Original Research, State-of-the-Art Review | Article, Review, Perspective |
Word cap (Original Research) | 5500 words main text | 6000 words | 5000 words | 3000 to 5000 words |
First decision (median) | 4 to 6 weeks | 4 to 6 weeks | 4 to 6 weeks | 2 to 4 weeks |
Open access | Hybrid | Hybrid | Hybrid | Hybrid |
Source: Clarivate JCR 2024, publisher author guidelines, SciRev author-reported medians (accessed May 2026).
Article types and what they mean for your submission
Article type | Key requirements |
|---|---|
Original Research Article | Default route for full mechanistic papers; manuscript must look complete, not exploratory; editors expect a clear biological question, multiple lines of evidence, method stability, a credible mechanistic model, and enough consequence to matter across cardiovascular biology |
Brief Report | Can work for a sharp mechanistic point with high significance; the shorter format must feel disciplined rather than incomplete; the scientific importance bar is not lower |
Review | Typically solicited; not the standard route for unsolicited original science; submitting as a Review does not bypass the mechanistic depth screen |
Source: American Heart Association, Circulation Research author guidelines
Do not try to rescue a thin paper by labeling it a different format. Editors will still assess whether the science looks finished, and a brief report that reads like an incomplete full paper is a recognizable pattern.
Before submitting to Circulation Research, a Circulation Research manuscript fit check identifies whether the package meets the editorial bar before you commit to the submission.
What editors screen first before peer review
The first pass is usually not about line-by-line methods. It is about editorial fit and consequence.
Editorial screen | Pass | Desk-rejection trigger |
|---|---|---|
Mechanistic depth | Manuscript explains how a cardiovascular process works, not just that something changes; causal closure is present in the figure sequence | Paper contains differential expression, observational correlation, biomarker association, or phenotype description without closing the loop on mechanism |
Evidence breadth | Evidence package combines complementary approaches: cell or molecular work, functional assays, in vivo validation, human tissue, or orthogonal mechanistic confirmation; evidence is proportionate to the claim | Mechanistic argument rests on one cell line, one mouse model, or one technique without orthogonal confirmation; single-system stories are harder here than at more specialized venues |
Cardiovascular significance | Result matters to the broader cardiovascular biology community; significance case travels beyond one narrow specialist audience | Manuscript is solid within one very narrow subfield but cannot make a credible case that the finding advances cardiovascular understanding more broadly |
Package stability | Figures carry the biological logic clearly; discussion stays proportionate; cover letter explains the mechanistic case specifically | Weak figure logic, abrupt discussion claims, underdeveloped controls, or a cover letter that sounds generic; at this level the package itself signals whether the paper is ready |
How to frame the manuscript before upload
The framing should help the editor see three things quickly:
- what biological problem the paper addresses
- what the manuscript explains mechanistically
- why that explanation matters to cardiovascular science now
That is a different framing from a general cardiology journal. You are not trying to sell immediate practice change. You are trying to show that the paper materially improves understanding of cardiovascular biology.
The easiest way to check that is to read only:
- title
- abstract
- first figure
- first paragraph of the discussion
If the mechanism still feels vague after that, the paper is not ready for this venue.
What a good cover letter should do
Your cover letter should not waste space flattering the journal. It should do four jobs.
Cover letter element | What to write | What to avoid |
|---|---|---|
Mechanistic question | State in one sentence what biological cardiovascular problem the paper resolves: not what the paper studied, but what causal understanding improved | Describing the disease context and the experimental approach without naming the mechanism the paper actually establishes |
Venue case | Explain why Circulation Research is the right home: basic cardiovascular mechanism, broad cardiovascular relevance, not primarily a clinical or epidemiological paper | Generic journal flattery or a venue case that would work equally for any AHA journal, regardless of whether the paper is mechanistic |
Evidence package | Identify the specific elements that make the mechanism credible: complementary models, causal experiments, validation logic, and the scope of the biological implication | Claiming the evidence is comprehensive without specifying the orthogonal elements that distinguish the package from single-system work |
Proportional significance | Commit to a specific mechanistic advance rather than broad disease relevance language | Promises about clinical translation or therapeutic potential that the current experimental work cannot support; editors flag overreach before it reaches reviewers |
Where submissions lose the editor early
Failure mode | What it looks like | How to fix it |
|---|---|---|
Paper still mostly descriptive | Manuscript contains modern assays and large datasets but does not close the loop on how the biology works; the mechanism is asserted in the discussion rather than demonstrated in the results | Add the causal experiments that connect the observation to the proposed mechanism; descriptive work that belongs in a different venue should be redirected rather than reframed |
Story depends on one narrow model | Mechanism rests on one cell line, one mouse model, or one isolated assay without orthogonal confirmation; the breadth of the conclusion outpaces the breadth of the evidence | Identify the most critical alternative explanation and add the experiment that rules it out, or acknowledge the model limitation explicitly and adjust the claim level accordingly |
Translational pitch outruns the basic science | Paper leans too hard on future therapeutic relevance before the underlying biology is established; the significance argument is clinical while the experimental work is still mechanistic scaffolding | Separate the mechanistic contribution from the translational aspiration; the basic science case should stand independently before clinical language is applied |
Manuscript belongs in a clinical journal | Real story is patient association, risk prediction, registry analysis, or outcome comparison without a mechanistic experimental component that would justify a basic-science venue | Either add the mechanistic experimental work that would justify Circulation Research or redirect to Circulation, JACC, or the appropriate AHA clinical journal |
Figures do not carry the argument | Cardiovascular biologist cannot follow the mechanistic logic from the figure panels alone; key steps are buried in supplementary material or dense methods sections | Restructure the figure sequence so the mechanism is legible from the main panels; supplement should support reproducibility, not carry the central argument |
Submit If
- the manuscript answers a mechanistic cardiovascular question
- the evidence package is broader than one isolated model
- the significance matters across cardiovascular biology
- the title and abstract already make the mechanism visible
- the paper reads like a finished biological story
Think Twice If
- the abstract is mainly observational or descriptive, and the first figure does not explain how a cardiovascular process works
- the story rests on one model, one sample type, or one assay without an orthogonal figure or table showing that the mechanism generalizes
- the methods do not close the causal step, so reviewers would need to ask for the key perturbation, rescue, validation sample, or protocol-level control
- the cover letter leans on clinical relevance because the manuscript does not yet provide a biological explanation of the cardiovascular mechanism
Comparison snapshot: where this fits versus nearby journals
Journal | Best fit | What usually loses fit |
|---|---|---|
Circulation Research | Broad mechanistic cardiovascular biology | Purely clinical or descriptive work |
Circulation | Clinical and translational cardiology with broad practice relevance | Basic mechanism without patient-facing consequence |
JACC family | High-impact clinical cardiology and subspecialty practice | Basic science centered manuscripts |
Cardiovascular Research | Strong cardiovascular mechanism with slightly broader translational flexibility | Papers needing the highest flagship-basic-science positioning |
That table is often the real submission decision. If the paper is strongest as a mechanistic biology manuscript, Circulation Research makes sense. If the clinical consequence is the main story, it usually belongs elsewhere.
Final checklist before you upload
- Is the manuscript clearly mechanistic from the title and abstract?
- Are the claims proportional to the evidence?
- Do the figures make the biological logic easy to follow?
- Does the package feel complete without relying on future experiments?
- Does the cover letter explain why this belongs in Circulation Research rather than a clinical cardiology journal?
If those answers are yes, the submission is much more likely to be treated as a serious fit rather than a fast editorial reject.
Before you upload, run your manuscript through a Circulation Research submission readiness check to catch the issues editors filter for on first read.
Official sources set the requirements, but the remaining question is manuscript fit. The review tells you whether your paper clears the Circulation Research fit check before upload, especially around descriptive cardiovascular association without causal mechanistic closure, single-model evidence stretched into a broad cardiovascular claim, and translational or clinical framing that outruns basic cardiovascular evidence. Paid Manusights reviews include a 60-day money-back guarantee, and we do not train models on submitted manuscripts.
Readiness check
Run the scan while Circulation Research's requirements are in front of you.
See how this manuscript scores against Circulation Research's requirements before you submit.
Decision risks before submitting to Circulation Research
Across cardiovascular manuscripts targeting Circulation Research, three desk-screen patterns recur because the journal is not a general cardiology outlet and not a descriptive translational-science venue. (Per AHA Circulation Research guidance and the journal's recent publication pattern, the paper has to read as causal cardiovascular biology: the abstract, first figure, methods, validation sample, controls, supplementary files, references, and cover letter all need to make the mechanism visible before the upload reaches the handling editor.) The patterns below are testable against your own manuscript before you commit the AHA journal page upload.
Descriptive cardiovascular association without causal mechanistic closure
Across cardiovascular manuscripts targeting Circulation Research, the most consistent failure mode is a paper whose disease association, omics signature, imaging readout, or phenotype is real but whose figure sequence still stops before mechanism. Circulation Research editors can usually see the gap in the abstract, Figure 1, methods, controls, and supplementary validation files.
The manuscript may show that a pathway, cell state, metabolite, transcript, electrophysiology feature, vascular phenotype, inflammatory program, or remodeling marker changes in disease, but it does not prove how that change drives the cardiovascular process.
Common component-level problems include a first figure that establishes association rather than causal direction, methods that rely on one perturbation without rescue, controls that rule out only the easiest alternative explanation, supplementary figures that bury the one mechanistic experiment, references that support plausibility rather than causality, and a cover letter that says "mechanistic insight" without naming the mechanism the paper actually establishes.
The fix is not cosmetic. The strongest Circulation Research-ready revision adds the decisive perturbation, rescue, knockout, dose-response, human-sample validation, orthogonal assay, or functional readout that connects molecular change to cardiovascular consequence.
If the paper remains primarily clinical association, biomarker discovery, or descriptive multi-omics after that check, the better redirect set is Circulation, JACC, European Heart Journal, Cardiovascular Research, Basic Research in Cardiology, or a specialty cardiovascular biology venue rather than Circulation Research.
Single-model evidence stretched into a broad cardiovascular claim
For manuscripts targeting Circulation Research, the second recurring pattern is an evidence package whose central claim depends too heavily on one model system.
The figure may be attractive, the methods may be competent, and the biology may be plausible, but the manuscript asks Circulation Research to accept a field-level cardiovascular conclusion from one mouse strain, one induced pluripotent stem cell line, one cell culture condition, one inhibitor, one sex, one time point, or one assay family.
At this tier, the abstract and cover letter need to explain why the mechanism generalizes across the relevant cardiovascular context. Editors and reviewers look for named manuscript components that de-risk overreach: independent validation cohorts, sex-aware analyses where relevant, in vivo and ex vivo agreement, multiple perturbation directions, rescue experiments, blinded quantification, hemodynamic or electrophysiology confirmation, and supplementary sensitivity tests.
When those components are missing, the discussion often overcompensates by promising therapeutic translation that the current figures cannot support. A realistic fix is to lower the claim, add orthogonal validation, or redirect.
Papers that remain narrow but solid may fit Cardiovascular Research, JACC: Basic to Translational Science, Basic Research in Cardiology, American Journal of Physiology Heart and Circulatory Physiology, Arteriosclerosis, Thrombosis, and Vascular Biology, or Journal of Molecular and Cellular Cardiology. A Circulation Research submission should make the model breadth proportionate to the claim before upload, not after reviewer request.
Translational or clinical framing that outruns basic cardiovascular evidence
Across Circulation Research-targeted manuscripts, the third pattern is a strong preclinical or patient-linked story framed as if it already supports a therapeutic, diagnostic, or practice-changing conclusion. Circulation Research can publish translationally meaningful work, but the title, abstract, methods, limitations, references, and cover letter still need to place the basic cardiovascular mechanism first.
The problem appears when the cover letter foregrounds future treatment, risk stratification, or clinical adoption while the figures mostly establish pathway behavior in a limited experimental setting. Reviewers then read the manuscript as overclaiming, even when the underlying biology is promising.
The manuscript components to audit are concrete: does the abstract name the mechanistic question before the translational promise; does the methods section include controls that separate mechanism from correlation; do the figures show functional consequence rather than only expression change; do the supplementary tables document sample inclusion, exclusion, and validation logic; do references compare against recent Circulation Research and Cardiovascular Research papers rather than broad clinical cardiology citations;
does the cover letter explain why Circulation Research is the right home instead of Circulation, JACC, European Heart Journal, JACC: Basic to Translational Science, Cardiovascular Research, or Nature Cardiovascular Research.
The fix is usually to right-size the claim: lead with the cardiovascular biology the manuscript proves now, state the translational implication as bounded, and keep limitations explicit. That posture reads stronger to Circulation Research editors than a clinical promise that the current package cannot yet defend.
Check whether your Circulation Research manuscript is submission-ready
Additional pre-submission review patterns for Circulation Research
For Circulation Research-targeted manuscripts, three patterns consistently predict desk-screen failure at Circulation Research (American Heart Association). The patterns below are the same ones the journal's handling editors and outside reviewers flag at first-pass triage.
Scope-fit ambiguity in the abstract. Circulation Research editors move fastest on manuscripts whose contribution is obviously aligned with cardiovascular basic-science research with mechanistic depth and translational implications. The named failure pattern: mechanism-only cardiovascular papers without translational-implication framing extend revision rounds. Check whether your abstract reads to Circulation Research's scope
Methods package incomplete for the journal's reviewer pool. Circulation Research reviewers expect specific methodological detail. Preliminary mechanistic claims without in-vivo validation extend reviewer consultation. Check if your methods package is reviewer-complete
Reference-list and clean-citation failure mode. Editorial team at Circulation Research (American Heart Association) screens reference lists for retracted-paper inclusion. Check whether your reference list is clean against Crossref + Retraction Watch
Editorial evidence signal for Circulation Research (American Heart Association). Our review of public author guidance, recent published article packages, and Manusights pre-submission review patterns points to this practical risk: Circulation research reviewers expect both mechanistic depth and translational-implication framing; mechanism-only papers without translational pathway extend revision. Treat this as a fit-and-artifact screen rather than a private outcome claim; official journal pages remain authoritative for submission mechanics and policy requirements.
Next steps before you submit
Good journal verdict: Is Circulation Research a Good Journal? An Honest Assessment
Submission strategy: How to Choose the Right Journal for Your Paper
Readiness check: 10 Signs Your Paper Isn't Ready to Submit
If you want a pressure test before you submit, Manusights can review whether your manuscript really clears the mechanistic depth and evidence bar that Circulation Research editors expect.
Frequently asked questions
Circulation Research uses the AHA (American Heart Association) submission system. Prepare a manuscript with mechanistic depth, cardiovascular significance, and a clear cover letter framing the contribution. Upload through the journal portal with complete supporting materials.
Circulation Research wants papers with mechanistic depth in cardiovascular biology. The journal is an AHA flagship requiring genuine mechanistic understanding of cardiovascular disease, not just correlative or descriptive findings.
Circulation Research is a selective AHA journal. The editorial screen focuses on mechanistic depth, cardiovascular relevance, and scope fit. Papers must demonstrate genuine mechanistic contribution to cardiovascular understanding.
Common reasons include insufficient mechanistic depth, weak cardiovascular relevance, narrow scope without broader significance, and common submission mistakes in cover-letter framing or scope positioning. The desk reject decision arrives quickly when papers stop at correlation without mechanistic closure.
Circulation Research first-decision triage typically returns in 4 to 6 weeks; papers passing desk go to 2 to 3 reviewers and return reports in 6 to 10 weeks. The format requirement is the AHA template with a 250-word structured abstract, 5500-word main-text cap, AHA reference style, ORCID for all authors, and AHA reporting checklist matched to study type.
Circulation Research operates an AHA hybrid open-access model. Subscription publication carries no author charge; the gold open-access option carries an APC fee covered by many institutional read-and-publish agreements with AHA Journals.
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