PLOS ONE Pre-Submission Checklist: Are You Ready to Submit?
Before you submit to PLOS ONE, use this checklist to verify methods depth, data availability, reporting completeness, and the specific items editors screen during soundness review.
Research Scientist, Neuroscience & Cell Biology
A research scientist with 10+ years across molecular neuroscience and cell biology, with a particular focus on synaptic biology, neural circuit function, and neurodegenerative mechanisms. Has prepared and reviewed manuscripts for PNAS, Neuron, Nature Neuroscience, eLife, and Nature Communications. Brings hands-on experience with the statistical and methodological expectations at high-impact neuroscience journals, including figures, supplemental data standards, and rebuttal letter strategy.
Journals reviewed for:
Neuron, PNAS, eLife, Nature Communications, Journal of Neuroscience
Research published in:
Published in PNAS, eLife, Nature Communications, and Journal of Neuroscience
Before you submit to PLOS ONE, use this checklist to verify methods depth, data availability, reporting completeness, and the specific items editors screen during soundness review.
Nature Methods often tells authors relatively quickly whether the method is the real contribution, but the real submission question is benchmarked utility, not just speed.
Neuron lists a USD 10,400 APC for optional open access. Here is what the fee means in practice.
Neuron often decides quickly at the desk, but the real cost comes later if the paper enters review. Mechanistic depth and revision burden matter more than one neat timeline number.
A practical Journal of Neuroscience submission process guide focused on what happens after upload, what editors test first, and how to interpret early movement.
CNS journals are among the hardest venues in biomedical research. Here is what reviewers actually look for and how pre-submission review helps close the gap before you submit.
Science rejects more than 90% of submissions at the desk, often within 2-4 weeks. Papers that go to peer review take 3-5 months for a first decision. Here's the full timeline.
A practical Cell Discovery fit verdict for authors deciding whether their manuscript is strong enough, broad enough, and complete enough for this open-access Nature Portfolio biology journal.
Cancer Cell fit verdict with key metrics, comparison to Nature Cancer and Cancer Discovery, and practical guidance for cancer biology authors.
Cell Metabolism fit verdict with key metrics, comparison to Nature Metabolism and Cell, and practical guidance for authors in metabolism research.
A practical Cell Systems fit verdict for authors deciding whether their manuscript is truly systems biology rather than biology plus computation.
A practical Annals of Oncology fit verdict for authors deciding whether their study is clinically important enough for the ESMO flagship oncology journal.
A practical Nature Reviews MCB fit verdict on best fit, weak fit, and when it is the wrong target.
A practical Chemical Society Reviews fit verdict for authors deciding whether their review proposal is broad, synthetic, and authoritative enough for Chem Soc Rev.
A practical MNRAS fit verdict for authors deciding whether their paper is a disciplined astrophysics submission with enough evidence, scope, and field relevance for a core astronomy journal.
A practical Diabetes Care fit verdict for authors deciding whether their paper has real clinical diabetes-management consequence.
A practical Current Biology fit verdict for authors deciding whether their paper is broad and concise enough for the journal.
A practical Chemical Engineering Journal fit verdict for authors deciding whether their paper is truly engineering-driven enough for CEJ.
Most researchers know peer review exists but haven't seen it from the reviewer's side. Here's the full process from submission to published decision - including where most papers die, what reviewers actually check, and how long each stage takes.
The discussion section is where many good papers lose reviewers. Here is the structure that works, what to cut, and the failures editors notice first.
Scientific Reports has one of the longest review timelines in open-access publishing: around 120 days on average. Here's what happens at each stage and why it takes so long.
Nature Communications gets 50,000+ submissions per year and accepts about 8% of them. The review process moves faster than most journals at this impact factor, but initial screening is strict.
Reviewers decide how they feel about your paper in the first 90 seconds. Most of that time is spent on the abstract. Here's how to make those seconds count.
PLOS ONE's median time to first decision is 35-45 days, but that number hides a lot of variation. Some papers get decisions in 18 days. Others wait 90+. Here's what determines your timeline and what y...
Neuroscience manuscripts face heightened scrutiny on reproducibility, statistical methods, and sample sizes. Here is what editors and reviewers at top neuroscience journals actually look for.
Physics manuscripts face specific scrutiny on computational reproducibility, error analysis, and whether the result provides genuine physical insight beyond the numbers.
Cell Stem Cell is quick to make the first editorial call, but the meaningful number is the full path from submission to acceptance. The journal moves fast when the story is wrong for it and much more slowly when the paper survives.
Molecular Psychiatry is faster than many authors fear at the first editorial pass, but the right way to read the journal is as a selective psychiatry-neuroscience filter with a materially longer full cycle than its first-decision number implies.
ScholarsReview is appealing as an all-in-one academic AI workflow, but the public site is thinner on pricing and policy detail than stronger competitors.
The useful way to compare AI pre-submission tools is not by hype but by job: triage, logic analysis, writing support, or workflow convenience.
How to avoid desk rejection at Molecular Psychiatry. Practical guidance on editorial screens, common triggers, and what to fix before submission.
Major revision doesn't mean your paper is in trouble. Minor revision doesn't mean you're home free. Here's what each decision actually signals.
If your Nature Neuroscience submission shows Under Consideration, here is what each status means, the timeline, and what passing the desk signals.
If your PLOS ONE submission shows Under Review or another editorial status, here is what each stage means, how long it typically takes, and when to contact the editorial office.
Nature Biotechnology (IF 41.7) publishes platform technologies that change what entire fields can do. Here's the editorial test, what gets desk-rejected in 4 days, and when Nature Methods or Nature is the better target.
A practical Nature Medicine fit verdict for authors deciding whether the manuscript is translationally strong, clinically meaningful, and mature enough.
PNAS is prestigious and genuinely selective, but the two-track submission system and the Significance Statement format create specific opportunities and traps. Here's what actually matters for your submission decision.
If your NEJM submission is under review, the immediate question is not prestige. It is what the clock now means and what you should do while the decision is pending.
Applied Catalysis B fit verdict with key metrics, comparison to ACS Catalysis and Journal of Catalysis, and practical guidance for environmental and energy catalysis authors.
Frontiers in Plant Science is a high-volume OA plant biology journal with IF 4.8. Here's when it fits, the Frontiers perception issue, and how it compares to Plant Cell, New Phytologist, and Plant Physiology.
Advanced Energy Materials (IF 26.0, Wiley, Q1) publishes energy materials where the energy consequence is central. Here is who should submit and how it compares to Joule, EES, and ACS Energy Letters.
Frontiers in Microbiology is a broad OA microbiology journal with IF 4.5. Here's when it fits, the Frontiers perception issue, and how it compares to mBio, AEM, and ISME Journal.
Immunity (JIF 26.3, Cell Press) uses academic editors who are working immunologists. This guide covers how that model differs from Nature Immunology, the Cell Press transfer system, and when Immunity is the right target.
Applied Energy (IF 11.0, CiteScore 19.0) is the mid-tier workhorse of energy research. This guide covers its scope, how it compares to Energy, Renewable Energy, and Joule, and when it is the right target.
Genome Biology is the BMC flagship for genomics and computational biology with IF 9.4. Here's when your paper fits, what editors want, and how it compares to Nature Genetics, Nucleic Acids Research, and Bioinformatics.
Applied Physics Letters (IF 3.7, AIP) is the standard physics communication journal for concise results. Here is who should submit and how it compares to PRL, Nano Letters, and Optics Express.
Bioinformatics fit verdict with key metrics, comparison to Nature Methods and Genome Biology, and practical guidance for computational biology tool and method authors.
Blood (IF 23.1) is hematology's flagship journal with $0 APC. This guide covers its community model, editorial pathways for thrombosis through malignancy, and how it compares to Nature Medicine, Leukemia, and Haematologica.
EMBO Journal fit verdict: IF 8.3, EMBO Press. Transparent peer review, double-blind option. Here is when it fits and when Molecular Cell or Cell Reports is smarter.
Bioresource Technology (IF 9.0, Elsevier) is a top-tier journal for biomass conversion, bioenergy, and bioprocessing. Here's who fits and who doesn't.
Ceramics International (IF 5.6, Elsevier) is the leading broad-scope ceramics journal. Here's how it compares to J. European Ceramic Society, J. American Ceramic Society, and Acta Materialia.
Chemical Communications fit verdict with key metrics, comparison to JACS and Angewandte, and practical guidance for concise chemistry results.
The Astrophysical Journal (IF 5.4, AAS/IOP) is the flagship US astronomy journal, running since 1895. Here's how it compares to MNRAS, A&A, and Nature Astronomy.
Chemical Reviews fit verdict with key metrics, comparison to Chemical Society Reviews and Nature Reviews Chemistry, and practical guidance for review authors.
J. Alloys Compd. (IF 6.3) is Elsevier's high-volume venue for alloy and intermetallic research. Here's when your paper fits, what editors expect, and how it compares to Acta Materialia, Scripta Materialia, and J. Materials Science.
Clinical Infectious Diseases (IF 8.2, IDSA) is the flagship clinical infectious disease journal. Here's how it compares to Lancet ID, JID, and Clinical Microbiology Reviews.
IJHE (IF 8.1) is the primary journal for hydrogen energy research, production, storage, fuel cells, safety. Here's when your paper fits, what editors reject, and how it compares to Applied Energy and J. Power Sources.
RSC Advances is a legitimate gold open-access chemistry journal with IF 4.6. This guide covers its sound-methodology review model, how it compares to PLOS ONE and Scientific Reports, and when it is the right call.
Energy (Elsevier) fit verdict: IF 9.4, systems-level energy research. Here is when it fits and when Applied Energy or Renewable Energy is smarter.
Brain (IF 11.7, Oxford Academic) occupies a unique position bridging bench neuroscience and clinical neurology. This guide covers its editorial identity, comparisons with Lancet Neurology and Nature Neuroscience, and when it fits.
Cell Stem Cell (IF 20.4, Cell Press) is the Cell family's stem cell flagship. Here is who should submit and how it compares to Cell, Nature Cell Biology, and Cell Reports.
A practical JAMA Oncology fit verdict for authors deciding whether the manuscript can change physician practice in oncology broadly enough for the JAMA Network.
Molecular Psychiatry (IF 10.1, Nature Portfolio) publishes the biological basis of psychiatric disorders. Comparison with Biological Psychiatry, American J. Psychiatry, and Nature Neuroscience.
Lancet Infectious Diseases (IF 31.0) is the top-ranked infectious disease journal. COVID changed its profile permanently. Comparison with Clinical Infectious Diseases, J. Infectious Diseases, and NEJM for ID trials.
Cell journal fit verdict with key metrics, comparison to Nature and Science, and practical submit-or-skip guidance for authors.
JBC (IF 4.0, ASBMB) has been the workhorse of biochemistry since 1905. Here's what the IF drop means, when JBC is still the right venue, and how it compares to Molecular Cell, EMBO Journal, and Biochemistry.
A practical Physical Review Letters fit verdict for authors deciding whether their result is broad and concise enough for a flagship physics letters journal.
Advanced Materials (IF 26.8, Wiley, Q1) is the top interdisciplinary materials journal. Here is who should submit, what the editors want, and how it stacks up against Nature Materials and ACS Nano.
The Lancet (IF 88.5) is the highest-impact general medical journal. Here's what the Research in Context panel actually tests, why global framing matters, and when NEJM, JAMA, or BMJ is the better target.
Nature is arguably the most prestigious scientific journal in the world. Here's what the data says about when your paper actually belongs here, what the 7-day desk rejection actually evaluates, and when Nature Communications or a field journal is the smarter target.
eLife changed its entire model in 2022. All submissions get published, then reviewed publicly. Here's what that means for your paper and whether the IF 6.4 is a fair reflection of the journal's quality.
PLOS ONE does not judge novelty, but it absolutely does judge methods, reporting, and data availability. Here is what the submission process actually looks like.
Science journal accepts ~7% of submissions. 80%+ desk rejected without review. Review time, what editors want, and how to improve your odds.
A practical PLOS Medicine fit verdict for authors deciding whether their paper has the global, policy-facing medical consequence the journal expects.
A practical PNAS submission guide focused on significance, broad-reader fit, and what must already be obvious before a manuscript goes to PNAS.
How long does Cell Reports take? Here's the real desk-review timeline, acceptance-rate context, and what usually triggers reviewer pushback.
A practical Neuron submission process guide covering what happens after upload, what editors screen for first, and what to fix before you submit.
A practical Nature Neuroscience submission process guide covering what happens after upload, what editors screen first, and how to interpret silence or delay.
Compare Neuron vs Molecular Cell: JIF 12.8 vs 19.5 (2024 JCR), scope differences, acceptance rates, and which journal fits your cell biology or.
Nature Neuroscience impact factor is 20.0 with a 5-year JIF of 24.8. Q1, rank 2/314. Comparisons, trend, and submission guidance.
Neuron impact factor is 15.0. CiteScore 22.1, SJR 6.755, SNIP 2.952. Q1, rank 9/314 in Neurosciences.
A practical Neuron fit verdict for authors deciding whether their neuroscience paper is broad and mechanistic enough for one of the strongest Cell Press journals.
A practical Nature Methods fit verdict for authors deciding whether the method is broadly enabling, benchmarked, and adoptable enough.
A practical Nature Immunology fit verdict for authors deciding whether the manuscript is broad, mechanistically decisive, and field-shaping enough.
A practical Nature Neuroscience fit verdict for authors deciding whether the paper is causal, broad, and mechanistically complete enough.
Molecular Cell (IF 16.6, Cell Press) is the Cell family's mechanism-focused sibling. Here is who should submit and how it compares to Cell, Nature Cell Biology, and EMBO Journal.
A practical Nature Reviews Cancer fit verdict: what the journal is actually good for, who should pitch, and when it is the wrong target.
A fit-first Remote Sensing verdict on what paper types belong here, what weak-fit submissions get wrong, and when another venue is smarter.
Journal of Cleaner Production (IF 10.0) is one of the highest-impact sustainability journals. This guide covers its editorial scope, how it compares to Resources Conservation & Recycling and MDPI Sustainability, and when it fits.
A practical Sensors fit verdict for authors deciding whether the manuscript is truly sensor-first, validated, and useful enough for this broad journal.
Journal of Neuroscience (IF 4.0) is the Society for Neuroscience flagship. Its IF has declined but it remains the broad-field society journal. Comparison with Nature Neuroscience, Neuron, Brain, and eNeuro.
A practical Sustainability fit verdict for authors deciding whether the manuscript has real systems, policy, or implementation value.
A practical STOTEN fit verdict for authors deciding whether their paper is broad, hypothesis-driven, and strong enough for a cross-sphere environmental audience.
A practical NAR fit verdict for authors deciding whether the manuscript or resource has durable value for the nucleic-acid community.
A practical BMJ fit verdict for authors deciding whether the manuscript is broad enough and transparency-ready enough for this journal.
eLife and PLOS ONE both challenged traditional peer review but built very different journals. eLife is a selective, high-quality biology journal. PLOS ONE is a megajournal for technically sound work. Here's why they're not interchangeable.
A practical NEJM fit verdict for authors deciding whether the manuscript is decisive enough and broad enough for a flagship clinical audience.
JAMA is the AMA flagship with IF 55.0 and 4% research acceptance rate. Here's when it's the right target, what the 2-day desk triage actually evaluates, and when NEJM, Lancet, or a JAMA Network specialty journal is the better choice.
Gut (IF 25.8, BMJ/BSG) is a top-3 gastroenterology journal with a signature strength in microbiome research. This guide covers its 4,000-word limit, new editorial expansions, and how it compares to Gastroenterology, J. Hepatology, and Lancet Gastro.
Lancet Oncology (IF 35.9) publishes practice-changing cancer research with a global perspective. 75% desk rejection rate. How it compares to JCO, Annals of Oncology, and JAMA Oncology.
A practical Science Translational Medicine fit verdict for authors deciding whether their work is translational, clinical, and complete enough.
Both are high-impact open-access multidisciplinary journals. Nature Communications has the higher IF. Science Advances is more selective. Here's how to choose.
You've hit submit. Now what? Here's everything that happens to your paper from that moment until you get a decision.
You just got desk rejected. Here's what that means, why it happened, and the step-by-step plan for what to do next.
With 18.5% success rate, 81.5% of early-career researchers don't get funded on first try. Here's how to protect your publication record and maximize your odds.
Headlines said budget cuts. Final numbers show budget went up. Both are true. Here's the full story of what happened with NIH funding in 2025.
Neuron Articles allow ~7,000 words with a mandatory 1,200 x 1,200 px graphical abstract. Cell Press numbered references, STAR Methods with Key Resources Table, and exhaustive electrophysiology documentation are required.
PLOS ONE impact factor is 2.6 (JCR 2024). h-index 589, 12M citations. The most-published journal in science. Honest assessment of what 2.6 means.
A practical Physical Review B submission process guide covering the APS portal workflow, editorial triage, peer review stages, and what each status means for authors.
A practical PLOS ONE submission guide covering what editors screen for, how to pass the soundness bar, and what must be ready before upload.
Publishing your first paper is one of the most disorienting parts of an academic career. Here's the full process, from choosing a journal to responding to reviewers.
PNAS and Science Advances are both broad-scope journals below Nature/Science but above most specialty journals. Here's how they compare.
Nature Communications is fast by high-impact journal standards. Desk decisions in under 2 weeks, first decisions in about a month. Here's exactly what happens at each stage.
Circulation is the flagship journal of the American Heart Association and one of the fastest major journals for desk decisions. Here's what the submission process looks like, what the editorial team prioritizes, and how to avoid the most common rejection reasons.
Science Advances rejects about 90% of submissions, most without external review. Here's the full breakdown: desk rejection patterns, how long each stage takes, and what makes the ~10% that get published.
PNAS accepts about 16-19% of direct submissions after a 54% desk rejection filter. The Significance Statement is the most important 120 words in your submission.
PLOS ONE's acceptance rate has dropped from 68% in 2015 to 31% today. That's not a sign the journal got harder to publish in. It's a sign of who's submitting now, and understanding that changes how you should read the number.
Scientific Reports has a 3.9 impact factor, 57% acceptance rate, and carries the Springer Nature name. Some researchers swear by it. Others question the model. Here's the honest answer on all of it.
Nature desk rejects 70% of submissions. Cell rejects 65%. Here's how to avoid desk rejection and get your paper to peer review.
The journal you pick matters more than most researchers think. A great paper sent to the wrong journal gets rejected. Here's how to match your manuscript to the right target.
Cancer Research (IF 16.6, AACR) is the default top venue for basic cancer biology. Here is who should submit and how it compares to Cancer Cell, Cancer Discovery, and Clinical Cancer Research.
Applied Surface Science (IF 6.9, Elsevier) is a mid-tier applied materials journal strongest for surface characterization with functional consequence. Here's how it compares and who should submit.
Astronomy & Astrophysics (IF 5.4, EDP Sciences/ESO) is the flagship European astronomy journal. Here's how it compares to ApJ, MNRAS, and Nature Astronomy.
Carbohydrate Polymers (IF 12.5, Elsevier) is a niche but high-impact journal for polysaccharide and carbohydrate-based materials. Here's who fits and who doesn't.
Clinical Cancer Research fit verdict: IF 10.2, AACR translational oncology. Here is when it fits and when Cancer Discovery or a disease-specific journal is smarter.
Fuel is Elsevier's flagship for fuel science and technology with IF 7.4. Here's when your paper fits, what gets desk-rejected, and how it compares to Applied Energy, Energy & Fuels, and Combustion and Flame.
Lancet Neurology (IF 45.5) is the #1 ranked clinical neurology journal and the hardest Lancet specialty journal to publish in. Here's what practice-changing neurology actually means and when Brain, JAMA Neurology, or Annals of Neurology is the better target.
Advanced Functional Materials (IF 19.0) sits between Advanced Materials and specialty journals. Here's the editorial distinction: function must drive the story, not composition.
ACS Nano is the ACS flagship for interdisciplinary nanoscience. Here's when the nanoscale makes your paper ACS Nano material, and when Nano Letters, Nature Nanotechnology, or Advanced Materials is the better fit.
Environmental Science & Technology fit verdict: IF 11.3, ACS flagship. Here is when it fits and when Water Research or J. Hazardous Materials is smarter.
Food Chemistry fit verdict: IF 9.8, Elsevier. Here is when it fits and when Food Hydrocolloids or JAFC is the smarter move.
JCP (IF 3.5, AIP) is THE chemical physics journal for theoretical, computational, and experimental molecular science. Here's when your paper fits, how it compares to J. Physical Chemistry, PCCP, and JCTC.
IJBM (IF 8.5) is Elsevier's main venue for biopolymer research, proteins, polysaccharides, nucleic acids. Here's when your paper fits, what editors want, and how it compares to Carbohydrate Polymers and Biomacromolecules.
Circulation Research (IF 16.2, AHA) is the top journal for basic and translational cardiovascular science. Here is who should submit and how it compares to Circulation, EHJ, and JACC.
Hepatology is the AASLD flagship with IF 15.8, the premier US liver journal. Here's when your paper fits, what editors want, and how it compares to J. Hepatology, Gut, and Lancet Gastroenterology.
Construction and Building Materials fit verdict: IF 8.0, Elsevier. Here is when it fits and when Cement and Concrete Research or Building and Environment is smarter.
European Heart Journal is the ESC flagship with IF 35.6, the highest impact factor in cardiology. Here's when your paper fits, what editors prioritize, and how it compares to Circulation, JACC, and JAMA Cardiology.
Frontiers in Immunology is a high-volume OA journal with IF 5.7 and a collaborative peer review model. Here's when it fits, the legitimacy question, and how it compares to J. Immunology, JEM, and Immunity.
Gastroenterology (IF 25.1, AGA) is the US GI flagship and counterpart to Gut. Here is who should submit and how it compares to Gut, Journal of Hepatology, and Lancet Gastroenterology.
21% of ICLR 2025 reviews were fully AI-generated. Not AI-assisted: fully written by an LLM. Here's what that means for your next submission and how to protect your work.
Most desk rejections aren't about bad science - they're about fixable problems editors spot in the first 60 seconds. Here's what they look for.
Molecular Cell often tells you quickly whether the paper is in range, but the real submission question is whether the mechanism is deep enough for a top molecular-biology review.
A practical Physical Review Letters submission process guide covering the APS portal workflow, divisional editor triage, the justification paragraph, and what each stage means.
Scientific Reports has a 57% acceptance rate, which sounds like a sure thing. About 30% of submissions never reach peer review. Here's what the editorial check actually evaluates and when Scientific Reports is the right choice.
NSMB has a focused audience and strict standards. JIF helps, but your structural and mechanistic depth matters much more.
Our reviewers include researchers like this one who have published in and reviewed for top journals. Get a structured pre-submission review before you submit.